Labile Hemoglobin A1cThreshold Is Useful in Identifying the Hemoglobin J Variant, Which Causes Falsely Low Hemoglobin A1cConcentrations

Heterozygote Hemoglobin J Iran in Combination with Hemoglobin H Disease

This is a report concerning a concurrent case of hemoglobin J Iran (Hb J Iran) and Hemoglobin H (Hb H) disease in an Iranian woman. The patient was coincidentally found during the course of routine pre-marital genetic counselling for her son. The diagnosis of heterozygote Hb J Iran for her son, ultimately led to the diagnosis of concurrent Hb J Iran and Hb H disease. The hematological examinati...

Very Low HbA1c Values in A Patient with Clinical Silent Hemoglobin Variant ( Hemoglobin J ) A Case Report

Glycohemoglobin (GHb) most accurately reflects the previous two to three months of glycemic control. According to the American Diabetes Association, GHb should be measured regularly in all patients with diabetes, and values should be maintained below 7% to prevent the risk of chronic complications. Herein, we report a case of a 71-year-old type 2 diabetic female patient with extraordinary low H...

Hemoglobin J-Oxford: effects on hemoglobin and erythrocyte function.

Hemoglobin Variant (Hemoglobin Aalborg) Mimicking Interstitial Pulmonary Disease

Hemoglobin Aalborg is a moderately unstable hemoglobin variant with no affiliation to serious hematological abnormality or major clinical symptoms under normal circumstances. Our index person was a healthy woman of 58, not previously diagnosed with hemoglobinopathy Aalborg, who developed acute respiratory failure after a routine cholecystectomy. Initially she was suspected of idiopathic interst...

Incidental findings of variant hemoglobin during hemoglobin A(1c) testing.

A variant hemoglobin fraction may be an incidental finding during HbA(1c) analysis using the G8 Tosoh HPLC analyzer, but it is unclear if the retention times and fraction patterns can reliably predict the findings of a high-performance liquid chromatography (HPLC) β-thalassemia program (Bio Rad Variant II analyzer). We chose 100 samples sent for HbA(1c) determinations (G8 Tosoh) with an inciden...